Excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR) is believed to be a primary mechanism of neuronal injury following stroke.Thus, many drugs and therapeutic peptides were developed to inhibit either the NMDAR at the cell surface or its downstream intracellular death-signaling cascades.Nevertheless, the majority of focal ischemia
The Gaussian noise distribution is typically used in dynamic state estimation (DSE) but it is not always true in practice because of abnormal system inputs, impulsive noise and measurement outliers.In this paper, a new robust DSE approach based on a Nintendo AC Adaptor new robust Lp norm based estimator and the cubature Kalman filter (CKF) is devel
The ability to extract relevant information is critical to learning.An ingenious approach as such is the information bottleneck, an optimisation problem whose solution corresponds to a faithful and memory-efficient representation of relevant information from a large system.The advent of the age of quantum computing calls for efficient methods that
Abstract Background Periodontal disease is suggested to increase the risk of atherothrombotic disease by inducing dyslipidemia.Recently, we demonstrated that proprotein convertase subtilisin/kexin type 9 (PCSK9), which is known to play a critical role in the regulation of circulating low-density lipoprotein (LDL) cholesterol levels, is elevated in